The role of phosphohydrolases in the mechanism of resistance of neoplastic cells to 6-thiopurines.
نویسندگان
چکیده
cell lines, whereas alkaline phosphohydrolase activity was 8 times greater in Sarcoma 180/TG. Alkaline phosphohydrolase activity was localized predominantly in particulate fractions from Sarcoma 180/TG, showed a pH optimum of 9.2, and hydrolyzed a wide variety of phosphate esters, including p-nitropheny (phosphate and 5'-nucleotides, such as 6-thioinosine 5'-phosphate. It is suggested that enhanced
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ورودعنوان ژورنال:
- Cancer research
دوره 31 11 شماره
صفحات -
تاریخ انتشار 1971